D-Biotin deficiency can lead to a range of symptoms that involve a variety of areas including skin, hair, nails, and the nervous system. The following is a detailed summary of the symptoms of D-Biotin deficiency:
1. Skin symptoms
Dry skin: D-Biotin deficiency affects the secretion function of sebaceous glands, leading to dry skin and even triggering itching and inflammation.
Skin inflammation: D-Biotin deficiency may make the skin become fragile and easily inflamed by external stimuli. Inflammation is common in the face, scalp, trunk area, and the extensor side of the limbs.
Skin flaking: With the aggravation of D-Biotin deficiency, the sebaceous glands on the skin will increase significantly, which may lead to skin flaking.
2. Hair Symptoms
Hair loss: D-Biotin is involved in the synthesis and metabolism of keratin, and a lack of D-Biotin will lead to impaired growth of keratinocytes, thus causing hair loss. Hair loss usually occurs at the end of the hair growth cycle and is characterized by gradual thinning of the hair, and may also begin in areas of faster hair growth such as the top of the head or the forehead.
Graying of hair: long-term lack of D-Biotin may also lead to teenage gray hair.
3. Nail Symptoms
Fragile nails: D-Biotin is a coenzyme necessary for keratin synthesis. A deficiency of D-Biotin affects the synthesis of methylmalonic acid monoamide, which in turn interferes with the normal metabolism of keratin, leading to thin, brittle nails, which may be accompanied by longitudinal ridges or transverse grooves.
Inguguinitis: D-Biotin deficiency leads to brittle nails, if the nails are inadvertently trimmed too short or traumatized, bacterial infection may be induced, and inguinitis occurs, most commonly around the nails of the fingers or toes, and the local area will be red, swollen, painful and other symptoms.
4. Neurological symptoms
Fatigue: D-Biotin deficiency may lead to energy metabolism disorders, indirectly affecting the body’s energy supply, making people feel tired and weak, which may be accompanied by sleep disorders.
Memory loss: D-Biotin deficiency affects the synthesis and release of neurotransmitters, which in turn interferes with the transmission and storage of information in the brain, leading to memory loss, manifested as inattention and loss of short-term memory.
Mood swings: D-Biotin deficiency may also cause mood swings, including anxiety, depression and other neurological disorders.
5. Other Symptoms
Loss of appetite: Improper diet such as long-term picky eating and partiality may lead to D-Biotin deficiency in the body, which in turn leads to symptoms of loss of appetite.
Edema: D-Biotin deficiency may lead to insufficient protein synthesis, decreased plasma albumin concentration, decreased plasma colloid osmotic pressure, and water will leak out from the blood vessels into the tissue interstitial space to form edema, which may first appear in the low-hanging parts of the body, such as the ankles.