Neohesperidin is a natural flavonoid extracted from plants in the Brassicaceae family (e.g., limes, Citrus aurantium) with a variety of biological activities and a wide range of applications.
1. Basic information
Chinese name: Neohesperin
English name: Neohesperidin
CAS No.: 13241-33-3
Molecular formula: C₂₈H₃₄O₁₅
Molecular weight: 610.56 g/mol
Properties: white crystalline powder, melting point 236～237℃, easily soluble in hot water and hot ethanol, insoluble in ether.
2. Biological Activity
Antioxidant:
In 1.1-diphenyl-2-trinitrophenylhydrazine (DPPH) radical scavenging assay, the IC₅₀ was 22.31 μg/mL, showing strong antioxidant capacity.
Anti-inflammatory and anti-allergic:
Inhibit the release of inflammatory mediators and alleviate allergic reactions.
Regulation of Glycolipid Metabolism:
Inhibit adipocyte differentiation, reduce triglyceride content, activate Akt/GSK3β signaling pathway.
Protect gastric mucosa:
Significantly inhibits HCl/ethanol-induced gastric damage, reduces gastric acid secretion and elevates gastric juice pH.
Anti-tumor:
Inhibits the growth of leukemia cells (e.g., Caco-2. CEM/ADR5000. CCRF-CEM) with IC₅₀ values of 0.17. 0.17. and 0.12 mM, respectively.
3. Application areas
Food industry:
As a natural sweetener, the sweetness is 1000 times that of sucrose (derivatives after hydrogenation can reach 1500-2000 times), suitable for fruit juice, beverage, pastry, etc., especially for diabetic patients.
Pharmaceutical field:
Used in drug formulations for the treatment of cardiovascular diseases, anti-inflammatory, antioxidant and regulation of glycolipid metabolism.
Cosmetics:
Utilizing its antioxidant and anti-inflammatory properties to develop anti-aging and whitening products.