Naringin (naringenin) has a wide variety of derivatives, the following are some of the main naringin derivatives and their related information:
1. Derivatives obtained through chemical modification
Naringin chalcone
Structural features: Naringenin chalcone is a chalcone derivative formed by further structural changes in naringenin obtained after hydrolysis of naringin.
Biological Activity: It has a variety of biological activities such as antibacterial, anti-inflammatory, scavenging free radicals, antioxidant and so on, and can be applied in the fields of medicine, food and so on.
Methylated or acetylated derivatives
Structural features: Naringin’s phenolic hydroxyl group and other active sites can be chemically introduced into the methyl group, acetyl group and other groups to form methylated or acetylated derivatives.
Biological activity: These derivatives may change the solubility, stability or biological activity of naringin, thus expanding its range of applications.
Glycosidized Derivatives
Structural Characteristics: The hydroxyl group of naringenin may undergo glycosidation with a sugar group to form glycosidized derivatives.
Biological activity: Glycosidation may improve the water solubility or bioavailability of naringenin, and enhance some of its biological activity.
2. Derivatives obtained through biotransformation
Enzymatic products
Structural characteristics: Naringin can remove the sugar group through enzymatic reaction to form naringenin and other enzymatic products.
Biological activity: naringin has stronger biological activity, such as antioxidant, anti-tumor, etc., which can be further used in drug research and development or functional food preparation.
Microbial transformation products
Structural features: The transformation of naringenin by microorganisms can obtain derivatives with new structures.
Biological activity: These derivatives may have unique biological activity, providing new candidate compounds for drug development or industrial application.
3. Derivatives with specific functions
Naringin Derivatives in Nano-delivery Systems
Structural features: naringin or its derivatives are combined with nanomaterials to form a nano-delivery system.
Biological activity: the nano-delivery system can improve the bioavailability, targeting and stability of naringin, and enhance its therapeutic effect or the utility of functional food.
Photosensitive Derivatives
Structural features: Naringin derivatives are photosensitized by chemical modification.
Bioactivity: These derivatives can undergo photochemical reactions under light irradiation to produce specific biological effects, such as photodynamic therapy.