Neohesperidin dihydrochalcone is a flavonoid derivative extracted from citrus natural plants and made by hydrogenation, with high sweetness, low calorie, good stability, antioxidant and many other properties, it has a wide range of applications in food, medicine, feed and cosmetics. The following is a detailed introduction to it:
1. Basic Information
Chinese name: Neohesperidin dihydrochalcone
Foreign name: Neohesperidin Dihydrochalcone
Abbreviation: NHDC
Type: Flavonoid derivative
Molecular formula: C28H36O15
Molecular weight: 612.58
CAS No.: 20702-77-6
Appearance: White or yellowish powder crystal
Melting point: 152~154°C
Solubility: 0.2g/L at 20℃, 653g/L at 80℃.
2. Biological activity and application
Food industry
Sweetener: The sweetness of NHDC is 1500~1800 times that of sucrose, with small calorie (8.36J/g), refreshing taste, long lasting aftertaste, and excellent shielding of bitterness. It is often used in combination with other sweeteners to improve sweetness, reduce cost and make the sweetness more pure.
Flavor regulator: NHDC can improve the taste and flavor of food, enhance the flavor of fruits, raise the threshold of bitter taste, and the effect of bitterness removal is obviously better than that of general sweeteners.
Application examples: Widely used in juice drinks, milk, fruit wines, desserts, baked goods, candies, chewing gum, flavored sauces, low-energy beverages, sauces, vinegar, betel nut, cold fruits and so on.
Pharmaceutical field
Pharmaceutical excipients: NHDC can be used as pharmaceutical excipients, such as sweeteners or flavor regulators, to improve the taste of drugs and enhance patients’ compliance with medication.
Physiological activity: NHDC has the effect of antioxidant, lowering cholesterol, lowering blood sugar, inhibiting gastric acid secretion, protecting liver, regulating immunity. For example, it can reduce the plasma cholesterol and neutral lipid content in animals, preventing cardiovascular complications such as atherosclerosis and vascular circulatory diseases; it can also significantly increase the plasma high-density lipoproteins (HDL) in animals and reduce blood sugar.
Application example: NHDC was used in the European version of Viagra and pediatric ibuprofen suspension to mask the bitter taste of the drug.
Feed Industry
Sweetener: NHDC, as a high-intensity sweetener product, can be used in feed after compounding with sodium saccharin to improve the palatability of feed and promote animal feeding and growth.
Application examples: In feed, orange peel sweetener can be used with sodium saccharin of NutriSweet, which can well mask the after-bitter and metallic taste of sodium saccharin, and make the sweetness and sweetness greatly improved, thus saving cost.
Cosmetic field
Raw material for cosmetics: NHDC has antioxidant property, which can remove free radicals in the skin, promote skin metabolism, reduce pigmentation and moisturize the skin. It can also be used in lipsticks, serums, water-based cosmetics, etc. to increase the fragrance and antioxidant effect of cosmetics.
Application Example: The total effective rate of 2% NHDC gel on melasma is 89.6%.